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Learning Disabilities Research Group
Department of Psychiatry
Section of Developmental Psychiatry
University of Cambridge
Douglas House, 18b Trumpington Road, CAMBRIDGE, CB2 8AH
United Kingdom

Enquiries & Reception:
+44 (0)1223 746124
+44 (0)1223 746100
FAX: +44 (0)1223 746122
Email: Sue Hampton-Matthews

Publications by members of the LDRG

2008

Clare, I.C.H. and Woodbury-Smith, M.R.

(in press).

Autism Spectrum Conditions, in (Eds.) S. Young, M. Kopelman and G. Gudjonsson.

Handbook of Forensic Neuropsychology. Oxford: Oxford University Press.

Dunn, M.C., Clare, I.C.H. and Holland, A.J.

(2008).

Substitute decision-making for adults with intellectual disabilities: Learning through experience.

Health Care Analysis. 16, 52–64. learn more / buy

Dunn, M.C., Clare, I.C.H. and Holland, A.J.

(2008).

To empower or to protect? Constructing the 'vulnerable adult' in English law and public policy.

Legal Studies. 28(2), 234-253. learn more / buy

Isles, A.R. and Wilkinson, L.S.

( 2008).

Epigenetics: what is it and why is it important to mental disease?.

British Medical Bulletin. 85, 35-45.

Keeley, H., Redley, M., Holland, A. and Clare, I. C. H.

(2008).

Participation in the 2005 general election by adults with intellectual disabilities.

Journal of Intellectual Disability Research. 52, (3), 175-181. learn more / buy

Luke, L., Redley, M., Holland, A.J. and Clare, I.C.H.

(2008).

Hospital clinicians’ attitudes towards a statutory advocacy service for patients lacking mental capacity: implications for implementation.

Journal of Health Services Research and Policy. 13 (2), 73 – 78. learn more / buy

Redley, M..

(2008).

Citizens with learning disabilities and the right to vote.

Disability & Society. 23 (4), 375 – 384. learn more / buy

Siaperas, P., Higgins, S., and Proios, P.

(In press).

Challenging behaviours in Autism: A case study on the effect of a residential training programme based on structured teaching and TEACCH method.

Psychiatriki (Greek Journal of Psychiatry).

DeVito, E., Blackwell, A.D., Kent, L., Ersche, K.D., Clark, L., Salmond,C>H., Dezsery, A.M. and Sahakian, B.J..

(2008).

The effects of methylphenidate on decision making in attention-deficit/hyperactivity disorder.

Biological Psychiatry. in press.

Langosch, J., Rand, S. Ghosh, B., Sharma, S., Tench, C., Stratton, R., D'Cruz, D., Trimble, M., Barrett, G. and Ring, H.

(2008).

A clinical electrophysiological study of emotional lability in patients with systemic lupus erythematosis (SLE).

Journal of Neuropsychiatry and Clinical Neurosciences. 20, 201 - 209

Webb, T., Maina E. N., Soni, S., Whittington, J., Boer. H., Clarke, D., and Holland A.

(2008).

In search of the psychosis gene in people with Prader-Willi syndrome.

American Journal of Medical Genetics. 146A (7), 843-53. learn more / buy
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2007

Ball, S.L., Holland, A.J., Treppner, P., Watson, P. and Huppert, F.A.

(2007).

Executive dysfunction and its association with personality and behaviour changes in the development of Alzheimer's disease in mild to moderately learning disabled adults with Down's syndrome.

British Journal of Clinical Psychology. 47, (1), 1-29 learn more / buy

Luke, L., Clare, I.C.H., Redley, M. and Holland, A.J.

(2007).

The Mental Capacity Act’s new Independent Mental Capacity Advocate (IMCA) service: its importance for psychologists.

Clinical Psychology Forum. 175, 52-56.

Craig, M.C., Zaman, S.H., Daly, E.M., Cutter, W.J., Robertson, D.M., Hallahan, B., Toal, F., Reed, S., Ambikapathy, A., Brammer, M., Murphy, C.M. and Murphy, D.G.

(2007).

Women with autistic-spectrum disorder: magnetic resonance imaging study of brain anatomy.

British Journal of Psychiatry. 191, 224-8. learn more / buy

Davies, W., Isles, A.R., Humby, T. & Wilkinson L.S.

(2007).

What are imprinted genes doing in the brain?.

Epigenetics. 2 (4), 201-6 learn more / buy

Davies, W., Humby, T., Isles, A.R., Burgoyne, P.S. & Wilkinson, L.S.

(2007).

X-monosomy effects on visuospatial attention in mice: a candidate gene and implications for turner syndrome and attention deficit hyperactivity disorder.

Biological Psychiatry, . 61(12), 1351-1360 learn more / buy

Dunn, M.C., Clare, I.C.H., Holland, A.J. and Gunn, M.J..

(2007).

Constructing and reconstructing 'best interests': An interpretative examination of substitute decision-making under the Mental Capacity Act 2005.

Journal of Social Welfare and Family Law. 29(2), 117-133.

Lambourne, S.L., Humby, T., Isles, A.R., Emson, P.C., Spillantini, M.G. & Wilkinson, L.S.

(2007).

Impairments in impulse control in mice transgenic for the human FTDP-17 tauV337Mmutation are exacerbated by age.

Human Molecular Genetics, 16(14):1708-1719.

Maina, E.N., Webb, T., Soni, S., Whittington, J., Boer, H., Clarke, D. & Holland, A.J.

(2007).

Analysis of candidate imprinted genes in PWS subjects with atypical genetics: a possible inactivating mutation in the SNURF/SNRPN minimal promoter.

Journal of Human Genetics, 52, 297-307.

Murphy, G.H., O’Callaghan, A.C. & Clare, I.C.H.

(2007).

The impact of alleged abuse on behaviour in adults with severe intellectual disabilities.

Journal of Intellectual Disability Research. 51 (10) 741-749

Redley, M., & Weinberg, D.

(2007).

Learning disability and the limits of liberal citizenship: interactional impediments to political empowerment.

Sociology of Health and Illness, 29 (5) 1-20.

Ring, H., Zia, A., Lindeman, S. & Himlok, K.

(2007).

Interactions between seizure frequency, psychopathology and severity of intellectual disability in a population with epilepsy and a learning disability.

Epilepsy and Behavior. 11 (1) 92-97

Ring, H.A., Sharma, S., Wheelwright, S. & Barrett, G.

(2007).

An electrophysiological investigation of semantic incongruity processing by people with Asperger's Syndrome.

Journal of Autism and Developmental Disorders. 37, 281-90

Sally-Ann Cooper and Anthony J. Holland. Edited by Nick Bouras and Geraldine Holt.

(2007).

Dementia and mental ill-health in older people with intellectual disabilities. in: Psychiatric and Behavioural Disorders in Intellectual and Developmental Disabilities 2nd Edition.

Chapter 10 pages 154-172, Cambridge University Press 2007 ISB-13 978-0-521-60825-1.

Stansfield, A., Holland, A.J. & Clare, I.C.H.

(2007).

The sterilisation of people with intellectual disabilities in England and Wales during the period 1988-1999.

Journal of Intellectual Disability Research, 51 (8) 569-579.

Suto, S., Clare, I.C.H., & Holland, A. J.

(2007).

Financial Decision-Making Guidance for supporting financial decision-making by people with learning disabilities.

British Institute of Learning Disabilities. ISBN 1 904082 96 3

Volkmar FR and Woodbury-Smith MR. (eds) Eric Hollander and Evdokia Anagnostou .

(2007).

The Clinical Diagnosis. In Clinical Manual for the Treatment of Autism.

New York: American Psychiatric Publishing, Inc.

Whittington J.E, Butler J.V., Holland A.J.

(2007).

Changing Rates of genetic subtypes of Prader-Willi Syndrome in the UK.

European Journal of Human Genetics, 15, 127-130.

Wilkinson, L.S., Davies, W. & Isles, A.R.

(2007).

Genomic imprinting effects on brain development and function.

Nature Reviews Neuroscience. Nov, 8 (11) 832-43

Zaman, S.H., Holt, G. & Bouras, N.

(2007).

Managing mental health problems in people with intellectual disabilities.

Published by Routledge, London. In Handbook of Intellectual Disability and Clinical Psychology Practice, Edited by A Carr; J McEvoy, P N Walsh & O'Reilly
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2006

Ball, S. L., Holland, A. J., Huppert, F. A., Treppner, P., Watson, P. & Hon, J.

(2006).

Personality and behaviour changes mark the early stages of Alzheimer's disease in adults with Down's syndrome: findings from a prospective population-based study.

International Journal of Geriatric Psychiatry, 21, 661-67.

Baron-Cohen S, Ring H, Chitnis X, Wheelwright S, Gregory L, Williams S, Brammer M. & Bullmore E.

(2006).

fMRI of parents of children with Asperger Syndrome: A pilot study .

Brain and Cognition. Volume 61, Issue 1, 122-130

Davies, W., Isles, A.R., Burgoyne, P.S. & Wilkinson, L.S.

(2006).

X-linked imprinting: effects on brain and behaviour.

Bioessays, 28(1), 35-44.

Hinton, E.C., Holland, A.J., Gellatly, M.S.N., Soni, S., Ghatei, M.A. & Owen, A.M.

(2006).

Neural Representations of hunger and satiety in Prader-Willi syndrome.

International Journal of Obesity, 30, 313-321.

Hinton E.C., Holland A.J., Gellatly, M.S.N., Soni, S. & Owen, A.M..

(2006).

An investigation into food preferences and the neural basis of food-related incentive motivation in Prader–Willi syndrome.

Journal of Intellectual Disability Research, 50, 633-642.

Isles, A.R., Davies, W. & Wilkinson, L.S.

( 2006 ).

Genomic imprinting and the social brain.

Philosophical Transaction of the Royal Society, Biological Sciences, 361(1476):2229-2237.

Isles A.R., & Humby, T.

(2006).

Modes of imprinted gene action in learning disability.

Journal of Intellectual Disability Research, 50(5), 318-25.

Murphy, G.H. and Clare, I.C.H. In (Eds.) A. Heaton-Armstrong, E. Shepherd, G. Gudjonsson and D. Wolchover.

(2006).

The effect of learning disabilities on witness testimony, Witness Testimony: Psychological, Investigative, and Evidential Perspectives.

pp.43-60. Oxford: Oxford University Press.

Redley, M., Luke, L., Keeley, H., Clare, I.C.H. and Holland, A.

(2006).

The Evaluation of the Pilot Independent Mental Capacity Advocate (IMCA) Service.

London: Department of Health. http://www.dh.gov.uk/PolicyAndGuidance/HealthAndSocialCareTopics/SocialCare/IMCA.

Sarah Ball, Tony Holland, Felicia Huppert, Peter Treppner and Karen Dodd.

(2006).

The Cambridge Examination for Mental Disorders of Older People with Down's Syndrome and others with Intellectual Disabilities (CAMDEX-DS).

Cambridge University Press 2006. ISBN-13 978-0-521-54794-9 and ISBN-10 0-521-54794-6.

Siaperas, P., & Beadle-Brown, J.

(2006).

A case study of the use of a structured teaching approach in adults with autism in a residential home in Greece.

Autism, 10, (4), 330-343.

Soni, S., Whittington, J., Holland, A.J., Webb, T., Maina, E.N., Boer, H. & Clarke, D.

(2006).

The course and outcome of psychiatric illness in people with Prader-Willi syndrome: implications for management and treatment.

Journal of Intellectual Disability Research, 51, 32-43.

Webb, T., Whittington, J., Holland, A.J., Soni, S., Boer, H., Clarke, D. & Horsthemke, B.

( 2006 ).

CD36 expression and its relationship with obesity in blood cells from people with and without Prader-Willi syndrome.

Clinical Genetics, 69, 26-32.

Woodbury-Smith, M.R., Clare, I.C.H., Holland, A.J. & Kearns, A.

(2006).

High functioning autistic spectrum disorders, offending and other law-breaking: findings from a community sample.

Journal of Forensic Psychiatry & Psychology, 17 (1), 1-13.

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2005

Baron-Cohen, S., Wheelwright, S., Robinson, J., Woodbury-Smith, M. R.

(2005).

The Adult Asperger Assessment (AAA): A diagnostic method.

Journal of Autism and Developmental Disorders. 35, 6

Dossetor, D.R., Santhanam, R., Rhodes, P., Holland, A.J. & Nunn, K.P.

(2005).

Developmental neuropsychiatry: A new model of psychiatry for young people with and without intellectual disability?.

Clinical Child Psychology and Psychiatry, 10(3), 277-303.

Isles, A.R., & Holland, A.J.

(2005).

Imprinted genes and mother-offspring interactions.

Early Human Development, 81, 73-77.

Jacob, R., Clare, I.C.H., Holland, A.J., Watson, P.C., Maimaris, C. & Gunn, M.

(2005).

Self-harm, capacity, and refusal of treatment: implications for emergency medical practice. A prospective observational study.

Emergency Medicine Journal; 22; 799-802.

Oliver, C., Holland, A.J., Hall, S., & Crayton, L.

(2005).

Effects of increasing task load on memory impairment in adults with Down's syndrome.

American Journal on Mental Retardation, 110(5), 330-345.

Stauder, J.E., Boer, H., Gerits, R.H., Tummers, A., Whittington, J. & Curfs, L.M.

(2005).

Differences in behavioural phenotype between parental deletion and maternal uniparental disomy in Prader-Willi Syndrome: an ERP study.

Clinical Neurophysiology, 116(6):1464-1470.

Suto, W.M.I., Clare, I.C.H., & Holland, A.J.

(2005).

Maximising capacity to make financial decisions.

British Journal of Clinical Psychology, 45, 261-266.

Suto, W.M.I., Clare, I.C.H., Holland, A.J., & Watson, P.C.

(2005).

Capacity to make financial decisions among people with mild intellectual disabilities.

Journal of Intellectual Disability Research, 49(3), 199-209.

Suto, W.M.I., Clare, I.C.H., Holland A.J., & Watson P.C.

(2005).

The relationships among three factors affecting the financial decision-making abilities of adults with mild intellectual disabilities.

Journal of Intellectual Disability Research, 49(3), 210-217.

Woodbury-Smith, M.R., Clare, I.C.H., Holland, A.J., Kearns, A., Staufenberg, E., & Watson, P.

(2005).

A case-control study of offenders with high functioning autistic spectrum disorders.

Journal of Forensic Psychiatry & Psychology, 16(4), 747-763.

Woodbury-Smith, M.R., Klin, A., & Volkmar, F.R.

(2005).

Asperger’s Syndrome: A comparison of clinical diagnoses and those made according to the ICD-10 and DSM-IV.

Journal of Autism and Developmental Disorders, 35(2), 235-239.

Woodbury-Smith, M.R., Robinson, J., Wheelwright, S., & Baron-Cohen, S.

(2005).

Screening adults for Asperger Syndrome using the AQ: a preliminary study of its diagnostic validity in clinical practice.

Journal of Autism and Developmental Disorders, 35(3), 331-335.

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2004

Ball, S.L., Holland, A.J., Huppert, F.A., Treppner, P., Watson, P. & Hon, J.

(2004).

The modified CAMDEX informant interview is a valid and reliable tool for use in the diagnosis of dementia in adults with Down's syndrome.

Journal of Intellectual Disability Research, 48(6), 611-620.

Goldstone, A.P., Thomas, E.L., Brynes, A.E., Castroman, G., Edwards, R., Ghatei, M.A., Frost, G., Holland, A.J., Grossman, A.B., Korbonits, M., Bloom, S.R. & Bell, J.D.

(2004).

Elevated fasting plasma ghrelin in Prader-Willi syndrome adults is not solely explained by their reduced visceral adiposity and insulin resistance.

Journal of Clinical Endocrinology and Metabolism, 89(4), 1718-1726.

Hinton, E. C., Parkinson, J. A., Holland, A. J., Arana, F. S., Roberts, A. C. & Owen, A. M.

(2004).

Neural contributions to the motivational control of appetite in humans.

European Journal of Neuroscience, 20 (5), 1411-8.

Joyce Whittington and Tony Holland. Eds.

(2004).

Prader-Willi Syndrome: Development and Manifestations.

Cambridge University Press. ISBN 0 521 84029.

Murphy G.H. and Clare I.C.H. In (Eds) D. Carson and R.H.C. Bull.

(2004).

Adults' capacity to make legal decisions, Handbook of Psychology in Legal Contexts, 2nd Edn.

2003 pp.31-66 Chichester: John Wiley & Sons .

Swatton, J.E., Sellers, Lynda A., Faull, Richard L.M., Holland, A.J., Iritani, Shuji, & Bahn, Sabine.

(2004).

Increased MAP kinase activity in Alzheimer's and Down syndrome but not in schizophrenia human brain.

European Journal of Neuroscience, 19, 2711-2719.

Veltman, M.W., Thompsons, R.J., Roberts, S.E., Thomas, N.S., Whittington, J. & Bolton, P.F.

(2004).

Prader-Willi Syndrome-a study comparing deletion and uniparental disomy cases with reference to autism spectrum disorders.

European Child and Adolescent Psychiatry, 13(1), 42-50.

Whittington, J.E., Holland, A.J., Webb, T., Butler, J.V. Clarke, D.J. & Boer, H.

(2004).

Underachievement in Prader Willi Syndrome.

Journal of Intellectual Disability Research, 48, 188-200.

Whittington, J.E., Holland, A.J., Webb, T., Butler, J.V. Clarke, D.J. & Boer, H.

(2004).

Cognitive abilities and genotype in a population-based sample of people with Prader-Willi syndrome.

Journal of Intellectual Disability Research, 48, 172-187.
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2003

Arana, F.S., Parkinson, J.A., Hinton, E., Holland, A.J., Owen, A.M. & Roberts, A.C.

(2003).

Dissociable contributions of the human amygdala and orbitofrontal cortex to incentive motivation and goal selection.

Journal of Neuroscience, 23(29), 9632-8.

Bellhouse, J., Holland, A., Clare, I.C.H., Gunn, M. and Watson, P.

(2003).

Capacity-based mental health legislation and its impact on clinical practice: 1) treatment in hospital.

Journal of Mental Health Law, 9-23. July learn more / buy

Bellhouse, J., Holland, A., Clare, I.C.H., Gunn, M. and Watson, P.

(2003).

Capacity-based mental health legislation and its impact on clinical practice: 2) treatment in hospital.

Journal of Mental Health Law, 24-37. July

Bellhouse, J., Holland, A.J. & Pickard, J.

(2003).

Psychiatric, cognitive and behavioural outcomes following craniopharyngioma and pituitary adenoma surgery.

British Journal of Neurosurgery, 17(4),319-326.

Holland, A., Whittington, J., Hinton, E.

(2003).

The paradox of Prader-Willi syndrome: a genetic model of starvation.

The Lancet, 362, 989-991.

Holland, A.J. & Clare, I.C.H.

(2003).

The Human Genome Project: considerations for people with intellectual disabilities.

Journal of Intellectual Disability Research, 47 (7), 515-525.

Holland, A.J., Whittington, J.E. Butler, J., Webb, T., Boer, H. & Clarke, D.J.

(2003).

Behavioural phenotypes associated with specific genetic disorders: evidence from a population-based study of people with Prader-Willi Syndrome.

Psychological Medicine, 33, 141-153.

Murphy, G.H. and Clare, I.C.H.

(2003).

Adults' capacity to make legal decisions.

Handbook of Psychology in Legal Contexts 2nd Edn., 2003 pp. 31-66. Chichester: John Wiley & Sons.

O’Callaghan, A., Murphy, G.H. & Clare, I.C.H.

(2003).

The impact of abuse on men and women with severe learning disabilities and their families.

British Journal of Learning Disabilities, 31, 175-180.

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2002

Boer, H., Holland, A.J., Whittington, J., Butler, J., Webb, T. & Clarke, D.

(2002).

Psychotic illness in people with Prader Willi Syndrome due to chromosome 15 maternal uniparental disomy.

The Lancet, 359, 135-136.

Butler, J., Whittington, J.E., Holland, A.J., Webb, T., Clarke, D., & Boer, H.

(2002).

Medical conditions in Prader Willi Syndrome.

Developmental Medicine and Child Neurology, 44, 248-255.

Clarke, D.C., Boer, H., Whittington, J.E., Holland, A.J., Butler, J.V. & Webb, T.

(2002).

Prader-Willi Syndrome, compulsive and ritualistic behaviours: The first population-based survey.

British Journal of Psychiatry, 180, 358-362.

Fenner, S., Gudjonsson, G.H. & Clare, I.C.H.

(2002).

Understanding of the current police caution (England and Wales) among suspects in police detention.

Journal of Community & Applied Social Psychology, 12, 83-93.

Goldstone, A.P., Brynes, A.E., Thomas, E., Bell, J.D., Frost, G., Holland, A.J., Ghatei, M.A. & Bloom, S.R.

(2002).

Resting metabolic rate, plasma leptin concentrations, leptin receptor expression, and adipose tissue measured by whole-body magnetic resonance imaging in women with Prader-Willi syndrome.

American Journal of Clinical Nutrition, 75, 468-475.

Holland, A.J., Clare, I.C.H. & Mukhopadhyay, T.

(2002).

Prevalence of 'criminal offending' by men and women with intellectual disability and the characteristics of 'offenders': implications for research and service development.

Journal of Intellectual Disability Research, 46 (supp 1), 6-20.

Ikeda, M., Brown, J., Holland, A.J., Fukuhara, R. & Hodges, J.

(2002).

Changes in appetite, food preference and eating habits in frontotemporal dementia and Alzheimer disease.

Journal of Neurology, Neurosurgery and Psychiatry, 73, 371-376.

Suto, W.M.I., Clare, I.C.H. & Holland, A.J.

(2004).

Managing money: the path to independent choice-making.

Living Well, 4(2), 11-16.

Suto, W.M.I., Clare, I.C.H. and Holland, A.J.

(2002).

Substitute financial decision-making in England and Wales: a study of the Court of Protection.

Journal of Social Welfare and Family Law, 24, 37-54.

Webb, T., Whittington, J.E., Clarke, D., Boer, H., Butler, J. & Holland, A.J.

(2002).

A study of the influence of different genotypes on the physical and behavioural phenotypes of children and adults.

Clinical Genetics, 62, 273-281.

Whittington, J.E., Holland, A.J., Webb, T., Butler, J.V., Clarke, D.J. & Boer, H.

(2002).

Relationship between clinical and genetic diagnosis of Prader-Willi Syndrome.

Journal of Medical Genetics, 39, 926-932.

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